Mitotic activity is associated with a shorter survival and is used as a grading criterion to distinguish infiltrating astrocytoma, WHO grade II from anaplastic astrocytoma, WHO grade III. Likewise, necrosis and microvascular proliferation signal
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Proliferative index in astrocytic tumours.
The accurate grading of astrocytic tumours is of prime importance because it is critical to the patient management and survival/outcome. Although internationally accepted WHO grading system of CNS tumours is based on histological features of H&E stained sections, yet there are cases where differentiation between grade II and grade III is difficult particularly when the biopsy is small. Prolifer...
متن کاملSupratentorial grade II astrocytoma: biological features and clinical course.
Because of its unpredictable clinical course, treatment strategies for low-grade (grade II) astrocytoma vary from "wait and see" to gross tumour resection followed by immediate radiotherapy. Clinical studies on grade II astrocytoma show that 5-year-survival ranges from 27% to 85% of patients with very few consistent prognostic variables besides the patient's age and the presence of neurological...
متن کاملDiffuse Infiltrating Oligodendroglioma and Astrocytoma. - PubMed - NCBI
The new 2016 WHO brain tumor classification defines different diffuse gliomas primarily according to the presence or absence of IDH mutations ( IDH-mt) and combined 1p/19q loss. Today, the diagnosis of anaplastic oligodendroglioma requires the presence of both IDH-mt and 1p/19q co-deletion, whereas anaplastic astrocytoma is divided into IDH wild-type ( IDH-wt) and IDH-mt tumors. IDH-mt tumors h...
متن کاملبررسی مقایسه‌ای دو رژیم شیمی‌درمانی تک‌دارویی و چنددارویی از نظر بقای کلی و عاری از بیماری در مبتلایان به آستروسیتوم گرید بالا
Background: The standard treatment for high-grade astrocytoma (grades 3 and 4) is surgery followed by radiotherapy (post-op RT). Adjuvant chemotherapy increases disease-free survival (DFS) and overall survival (OS). There are several drugs used for this purpose, each of which have shown benefits and shortcomings. The superiority of combination therapies such as PVC (procarbazine, CCNU and vincr...
متن کاملDifferential proteomics analysis of low- and high-grade of astrocytoma using iTRAQ quantification
Astrocytoma is one of the most common types of brain tumor, which is histologically and clinically classified into four grades (I-IV): I (pilocytic astrocytoma), II (diffuse astrocytoma), III (anaplastic astrocytoma), and IV (glioblastoma multiforme). A higher grade astrocytoma represents a worse prognosis and is more aggressive. In this study, we compared the differential proteome profile of a...
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تاریخ انتشار 2016